Congrats to newly minted PhD candidate Sam Courtney for successfully passing her preliminary exam!
Stay tuned to learn about her research “Investigating viral population diversity of deer tick virus during tick transmission and mammalian infection“.
Greg Ebel was recently featured on the Living Healthy Longer podcast, hosted by Columbine Health Systems Center for Healthy Aging at Colorado State University. 
In the episode “From Virus to Virus with Dr. Greg Ebel“, Dr. Ebel discusses his lab’s history of surveillance and prevention strategies for arboviruses (West Nile, dengue and Zika viruses), and how that work poised his team to respond to the COVID-19 pandemic early in 2020.
Speaking on emerging virus threats for the future – “Here on planet earth, we have some really big, hard problems that are not in anyway straightforward to address….this is symptomatic of a much larger, much deeper, much more complicated set of problems that as society, as humanity, as people who live here on planet earth, we gotta figure out how to handle those things.”
Take a listen and let us know what you think!
Huge congratulations to PhD candidate Emily ‘Fitz’ Fitzmeyer for winning CSU Microbiology, Immunology and Pathology Department’s Graduate Student Research Excellence award! You can read Fitz’s recently published PLoS Pearl on barcoded viruses here – Scanning barcodes: A way to explore viral populations
You can read about all the 2023 Graduate Student Excellence Award winners here!
And congrats to undergraduate research assistant MaKala Herndon on presenting her thesis project “The Application of Gene Drive in Preventing the Transmission of Vector Borne Diseases”!
Congrats to PhD student Bekah McMinn for successfully defending her dissertation “A Circuitous Journey of Virus Characterization and Surveillance in North and Central America“.
You can read about some of Bekah’s recently published work here – Phylodynamics of deer tick virus in North America.
Today we present an ongoing project within the lab! The missive below goes into greater detail about the Verena (Viral Emergence Research Initiative) Biology Integration Institute, a collaboration between many scientists of many backgrounds intending to discover more about the science of the host-virus network. Led by Georgetown University, this initiative will involve affiliate faculty member Dr. Anna Fagre, as well as Greg working to greater explore the “interactions between bats and mosquitoes… whether bats can serve as a reservoir or amplification hosts for arboviruses in nature.” Dr. Susan VandeWoude, dean of CVMBS, will serve on the institute’s science policy advisory board.
Anna is also working on a podcast through the initiative, which will aim to explore efforts by early-career scientists working on viruses. It’s multi-disciplinary approaches to science and public interaction, like these, that further both our understanding of the world around us as well as the goal of aiding public understanding into what exactly we do in these strange buildings called laboratories.
This article, via cvmbs.source from 2022, goes into more detail.
Howdy, Ebel Lab Fans!
Xenosurveillance has been an ongoing project in the lab for many years. The goal has been to bring low-cost, noninvasive surveillance into resource-poor and vulnerable settings, including Senegal, Liberia and most recently Guatemala. The effort has involved several trainees including Doug Brackney, Nathan Grubaugh, Joseph Fauver, James Weger-Lucarelli, Claudia Ruckert, Bekah McMinn, Delaney Worthington, Emma Harris, and a range of collaborators including Brian Foy, Dan Olson and Valeria Scorza. The project has been funded by the US Department of Defense, the CSU Office of the Vice President for Research and One Health Institute and the US National Institutes of Health.
It’s great to see xenosurveillance and community efforts around disease-monitoring getting attention on a large platform, and a pleasant reminder that science need not happen within a vacuum. Viruses don’t care about borders, and nor should our efforts at disease monitoring and prevention.
The article (also available in audio format on the same page):
Hello, Ebel Lab Science Enthusiasts!
Admittedly, it’s been some time since our last post. There’s this whole pandemic ~thing~ that we all got caught up in. We got busy.
As we move into 2023, we thought it prudent to do a kind of retrospective on Ebel Lab-folk-in-the-news before continuing on with your regularly scheduled programming. These posts are by no means an exhaustive list of the goings-on about the lab, but a brief primer on what you may have missed these past tumultuous years.
– Here, you will find a link to Greg being interviewed about WNV evolution and xenosurveillance for the American Society for Microbiology’s “Meet the Microbiologist” podcast: https://asm.org/Podcasts/MTM/Episodes/Arbovirus-evolution-with-Greg-Ebel-MTM-129
The interview begins with an excellent and succinct definition of xenosurveillance, then goes on to cover RNAi, viral replication within mosquitoes as a vector, WNV transmission, viral genetics, the list goes on. There’s a lot of good information within the conversation, and it serves as an excellent introduction to the kinds of work we’re invested in. There’s also great information within the show notes below the player, if you’re the kind of learner who prefers their information in a text-based format.
The show is a regular source of good information, so give them a follow/subscribe!
Image via: American Society for Microbiology, accessed 18 Jan. 2023, <https://asm.org/Podcasts/MTM/Episodes/Arbovirus-evolution-with-Greg-Ebel-MTM-129 >
Nextstrain is an open source project using genomic epidemiology to perform real-time tracking of pathogen evolution. The goal is to improve epidemiological understanding and outbreak response using openly shared data from research groups around the world.
This build, which incorporates data from the Ebel lab and which is based on the work of Cole Jensen and Anderson Brito of the Grubaugh Lab (Yale School of Public Health), uses genetic data and metadata of SARS-CoV-2 that has been openly shared by many research groups.
Ebel lab undergraduate research assistant Parker Cline was instrumental to this collaboration. See his contribution below, as well as a link to the Nextstrain project main page.
https://nextstrain.org/community/parkercline/CSU-SARS-CoV-2/ncovupdate
http://grubaughlab.com/nextstrain/
DISCLAIMER: These builds use preliminary data.
The Ebel lab’s COVID-19 surveillance work was again featured in the Colorado Sun. The project, a collaboration with Nicole Ehrhart and CSU’s Healthy Aging Center, is beginning to reveal clues about how SARS-CoV-2 spreads within skilled nursing facilities across the state. From the article:
“The team is among the first in the state to attempt to track the spread of the coronavirus by conducting genomic sequencing — the painstaking process of reading the virus’ genetic code. By looking for slight mutations in the code, researchers can create something of a family tree, showing which cases are closely related and which are more distantly separated.
And, though they still have plenty of work to do, the researchers’ data — gathered from dozens of samples from infected workers at nursing homes and other long-term care facilities — are showing a clear trend.”
Streets near Frasier Meadows, left, a campus of senior apartments and skilled nursing care in Boulder, are marked for the safety of older residents in the neighborhood. The doors at the complex are closed to visitors because of fears about the coronavirus. During a COVID-19 outbreak at the facility, three cases of the illness were confirmed among residents, and eight cases were confirmed or suspected among staff. No deaths were reported at the facility. (Dana Coffield, The Colorado Sun)
“Nicole Sexton, a postdoctoral fellow in Ebel’s lab, did much of the tedious work. Overall, she said, there wasn’t much variation between any of the samples. That’s to be expected because coronaviruses contain proofreading mechanisms to limit the natural mutations that occur as the virus replicates.
But what little variation there was showed a distinct pattern.
‘What we saw is within facilities a lot of the same sequence, whereas within different facilities, they had a different sequence,” she said. “It does look like, with the data we have so far, that they really are clustering within the same facility.'”
With thanks to Colorado Sun reporter John Ingold!
The Ebel lab’s SARS-CoV-2 collaboration with CSU’s Healthy Aging Center was recently featured on CPR. With support from the Colorado Department of Public Health & Environment (CDPHE), the coronavirus surveillance testing effort will soon expand rapidly to long-term care facilities around the state. From the article:
“The new study will help paint a picture of how COVID-19 spreads in complex facilities like residential nursing homes. Both state officials and researchers hope that the testing could mark a turning point in controlling COVID-19 in the beleaguered facilities.
Through this new effort, CDPHE and CSU will administer around 45,000 nose swab tests. These will be performed on staff members and some residents that are permitted to leave the facility during the lockdown for essential health appointments.
“The idea is to catch people as they become positive and then isolate them,” Erhart said.”
With thanks to CPR reporter Lindsay Fendt!
